As promised, we will maintain the organization of the World Congress every two years. The 3rd World Science & Wine Congress will be from 14 to 16 June 2023 in Vila Nova De Gaia and the Douro region. The topic for this scientific meeting here will be “Sustainability of wine production and food systems in the Mediterranean region”.

Interest of polyphenols in the prevention of age-related diseases and in regenerative medicine
7-ketocholesterol and 7β-hydroxycholesterol are two oxysterols mainly formed by the autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes. These two oxysterols are often observed at increased amounts in biological fluids as well as tissues and organs affected during age-related diseases and in diseases of civilization such as cardiovascular, neurodegenerative, and ocular diseases as well as type 2 diabetes and metabolic syndrome. Many nutrients present in significant amounts in the Mediterranean diet, especially tocopherols, fatty acids, and polyphenols, have shown cytoprotective activities as well as several Mediterranean oils (argan and olive oils, milk thistle seed oil, and pistacia lentiscus seed oil). Consequently, a nutraceutical approach, rich in nutrients present in the Mediterranean diet, could thus make it possible to counteract certain age-related and civilization diseases associated with increased levels of 7-ketocholesterol and 7β-hydroxycholesterol.

Festa do Tomate Coração de Boi do Douro
O Tomate Coração de Boi, que embeleza as hortas durienses e transmontanas durante o mês de agosto, é um fruto carnudo e sumarento muito apreciado por todos. Dada a sua importância para a região, desde 2016 que se organiza um evento festivo que visa promover este fruto, que encontra no Douro e em Trás-os Montes, ótimas condições para o seu amadurecimento.
The Tomate Coração de Boi, which beautifies the Douro and Trás-os-Montes vegetable gardens during August, is a fleshy and juicy fruit much appreciated by everyone. Given its importance to the region, since 2016 a festive event has been organized to promote this fruit, which is found in the Douro region and Trás-os Montes, with excellent conditions for its ripening.

Influence of Mediterranean Diet on Human Gut Microbiota
Gut microbiota changes correlate with health status. Literature data on gut microbiota show that all dietary changes can induce the alteration of gut microbiota composition. Mediterranean diet (MD) is associated with a reduction of all-cause mortality and in this review, Giuseppe Merra and collaborators analyzed its interactions with human microbiota. In particular, they explored the modulation of the human microbiota, in response to MD adherence, focusing the attention on polyphenols, polyunsaturated fatty acids (PUFA)ω-3 and fiber. Evidences suggest that MD is able to modulate the gut microbiota, increasing its diversity. In fact, a Mediterranean-type dietary pattern is associated with specific gut microbiota characteristics. The available evidence, suggests that gut microbiota of subjects that follow a MD is significantly different from subjects that follow a Western diet model.

Olive oil and exercise: sharing the same path to better health?
An olive oil (OO) rich diet or high-intensity interval training (HIIT) independently improve markers of health and energy metabolism, but it is unknown if combining OO and HIIT synergize to improve these markers. This study characterized the isolated and combined impact of OO and HIIT on markers of health and energy metabolism in various tissues in C57BL/6J female mice. The results highlight the pleiotropic effects of OO and HIIT, although their combination does not synergize to further improve most markers of health and energy metabolism.

Mediterranean Diet and Physical and Fitness in Adults
A healthy diet and high health-related physical fitness levels may be part of an overall healthy lifestyle. The relationship between adherence to the Mediterranean diet and physical fitness levels has been analyzed in several studies. However, no studies have synthesized evidence on this relationship throughout adulthood. Moreover, in addition to the overall Mediterranean dietary pattern, the associations of individual components of the Mediterranean diet with physical fitness indicators are also unclear.

Separation and Determination of Biophenols in Olive Oil Samples Based on the Official Method of the International Olive Council and Commission Regulation (EU) No. 432/2012
The purpose of this study was to evaluate the key quality characteristics of olive oil with a main focus on the biophenolic content, its beneficial effects on health and the contribution of various quality characteristics to its health claims, as well as its influence from various parameters.

Food Habits of the Mediterranean Diet are Associated with Better Metabolic Features in Youths with Type 1 Diabetes
The aim of this study was to evaluate adherence to the Mediterranean diet (MedDiet) among children and adolescents with type 1 diabetes (T1D) in relation to metabolic control. Adherence to the MedDiet was assessed with the Mediterranean Diet Quality Index (KIDMED) questionnaire and physical activity by the International Physical Activity Questionnaire for Adolescent (IPAQ-A) on 65 subjects (32 males, 9–18 years) with T1D. The promotion of the MedDiet, mainly having a healthy breakfast, is a good strategy to include in the management of T1D to improve glucose and metabolic control. This research is valuable for parents to obtain the best results for their children with T1D.

Mediterranean Diet and Risk of COVID-19
Mediterranean dietary pattern is more important than that of its individual food groups. On one hand, for some foods, there was not a big difference between the most extreme consumption categories; therefore, the effect of high or low consumption would be more difficult to be observed. As more foods are included, these differences will grow. On the other hand, although we found a significant inverse association between dairy products and COVID-19, the effect of the Mediterranean diet is the combined effect of all its components, which can combine and enhance each other. Undoubtedly, the recommendation of a complete pattern is much more effective than that of isolated foods.

Cardioprotective Effects of Olive Oil
Cardiovascular diseases (CVDs) are still the leading cause of death and disability worldwide, and they could be prevented by a diet modification and a healthy lifestyle. Dietary modifications include a reduction in the consumption of saturated fatty acids and replacing them with mono or polyunsaturated fatty acids. Olive oil is a monounsaturated fatty acid, and its increased consumption has been associated with a significant reduction of CVDs